Chloroquine and a related compound, hydroxychloroquine — which was heavily touted by Trump — were reviewed earlier this year by a medical agency of the European Union after notification from Spain’s drug authority of six cases of mental disturbances linked to coronavirus patients on high doses of the medicines.
The European Medicines Agency revealed the latest concerns Friday and has recommended that the product information for the medicines be updated to inform health care professionals of the psychiatric risks.
Trump said in May that he had been taking hydroxychloroquine for “weeks” as a coronavirus preventative. “What do you have to lose?” he asked reporters. He said the drug, taken with an antibiotic, had the potential to be “one of the biggest game-changers in the history of medicine.”
When Trump did test positive for COVID-19 in early October, he didn’t take hydroxychloroquine. He was treated with Regeneron Pharmaceuticals’ then-experimental cocktail of monoclonal antibodies and a second antiviral drug, remdesivir. The federal Food and Drug Administration earlier this month granted emergency authorization to use the Regeneron treatment as well as remdesivir in combination with another drug in the battle against COVID-19.
The EMA statement noted that neither chloroquine nor hydroxychloroquine is authorized for the treatment of COVID-19, but that “both medicines have been used as off-label treatment in patients with the disease.” It added: “However, chloroquine and hydroxychloroquine have not shown any beneficial effects in treating COVID-19 in large randomized clinical trials.”